Therapeutic Targets and Mechanisms for Treatment
Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutics is directed to cope with the symptoms of the disease. Here we describe the efforts dedicated to attack the plaques and, in more detail, the process of neurofibrillary degeneration, linked to the presence of the hyperphosphorylated microtubule associated protein tau. We have identified the different putative targets for therapeutics and the current knowledge on them.
Treatment for Alzheimer's disease is entering a new and exciting phase, with several new drugs beginning clinical trials. Many of these new therapies are based on our best current understanding of the pathogenesis of Alzheimer's disease, and are designed to try to either slow or halt the progression of the disease. There are several different theories underlying the current efforts, and these are briefly reviewed. Therapies directed against some aspect of beta-amyloid formation, against neurofibrillary tangle formation and against the inflammatory response are all considered, as are the problems associated with each area. It is as yet unclear which, if any, of these approaches will be successful, but the high level of activity in each of these three fields provides some hope that an effective treatment for Alzheimer's disease is on the horizon.
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Recommended Sessions
- Alzheimer’s disease
- Alzheimer’s disease and Type 2 Diabetes
- Alzheimer’s disease Diagnosis and Symptoms
- Alzheimer’s disease Imaging
- Alzheimer’s disease Pathophysiology and Disease Mechanisms
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- Animal Models and Translational Medicine
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- Sleep Disorders - Psychiatric 2021 (USA)
- Sleep Disorders - Psychiatry Conference 2022 (France)
- Sleep Disorders - Psychiatry Congress 2021 (France)
- Social Psychology - Euro Psychiatry 2022 (Italy)
- Social Psychology - Psychiatry Conference 2022 (France)
- Social Psychology and Covid-19 - Psychiatry Conference 2021 (Germany)
- Social Science and Humanities - Psychology Health 2021 (Hungary)
- Sociology - Forensic 2021 (Czech Republic)
- Stress - Psychiatric Congress 2021 (Netherlands)
- Stress and Pain Management - Mental Health Summit 2021 (Czech Republic)
- Stress Management - Mental Health Congress 2021 (Germany)
- Stress, Anxiety and Depression - Psychology 2021 (UK)
- Stress, Anxiety and Depression - Psychiatry Mental health 2021 (Belgium)
- Stress, Anxiety and Depression - Psychiatry Meet 2021 (France)
- Stress, Anxiety and Depression - Annual Mental Health 2021 (Spain)
- Stress, Depression and Anxiety - Psychology Health 2021 (Hungary)
- Stress, Depression and Anxiety: - Psychologists Psychiatrists 2021 (Canada)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2021 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2021 (Spain)
- Suicidal Risk - Mental Health Congress 2021 (Germany)
- Suicide and Self harm - Mental Health Summit 2021 (Czech Republic)
- Suicide and Self harm - Mental Health Nursing 2021 (Canada)
- Suicide and Self harm - Psychologists Psychiatrists 2021 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2021 (Canada)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicidology and Suicide Prevention - Psychiatric Congress 2021 (Netherlands)
- Telepsychiatry - Psychiatry Congress 2021 (France)
- The Psychological and Social Impact of Covid-19 - Psychologists Meet 2021 (Netherlands)
- The role of psychiatrists during Covid-19 - Psychiatry Conference 2021 (Germany)
- Therapeutic Targets and Mechanisms for Treatment - Alzheimer’s disease 2021 (UK)
- Track 10: Emergency Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 11: Stress and pain management - Psychiatry Summit 2022 (Czech Republic)
- Track 12: Palliative and Hospice - Psychiatry Summit 2022 (Czech Republic)
- Track 13: Neuroscience and Neuropsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 14: Sports, Social and Military Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 15: Psychosomatic Medicine - Psychiatry Summit 2022 (Czech Republic)
- Track 16: Experimental Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 17: Yoga and Meditation - Psychiatry Summit 2022 (Czech Republic)
- Track 18: Forensic Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 19: Alzheimer’s and Dementia - Psychiatry Summit 2022 (Czech Republic)
- Track 1: Psychiatry and Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 20: Research, Education and Case Studies on Mental Health - Psychiatry Summit 2022 (Czech Republic)
- Track 2: Child and Adolescent Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 3: Mental Health and Psychiatric Nursing - Psychiatry Summit 2022 (Czech Republic)
- Track 4: Addiction Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 5: Telepsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 6: Anxiety and Depression Disorders - Psychiatry Summit 2022 (Czech Republic)
- Track 7: Midwifery & Women’s Health - Psychiatry Summit 2022 (Czech Republic)
- Track 8: Cross Cultural Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 9: Human Cognition - Psychiatry Summit 2022 (Czech Republic)
- TRAUMA - Psychiatry Congress 2022 (Czech Republic)
- Trauma Stress-Related Disorders - Psychiatry Conference 2022 (France)
- Vascular Dementia - Alzheimer’s disease 2021 (UK)
- Vestibular Disorders - EURONEURO 2021 (France)
- Wellness and Health Care - Annual Mental Health 2021 (Spain)
- Women and Mental Health - Psychiatric 2021 (USA)
- Women Mental Health and Illness - Psychiatry Meet 2021 (France)
- Women Mental Health and Illness In times of Covid-19 - Psychiatry Conference 2021 (Germany)
- Women’s Health and Midwifery - Annual Mental Health 2021 (Spain)
- Women’s Mental Health and Disorders - Euro Psychiatry 2022 (Italy)
- Women’s Mental Health and Midwifery - Psychiatry Congress 2021 (France)
- Women’s Psychology - Psychology 2021 (UK)
- Womens Mental Health - Psychiatry Congress 2021 (Germany)
- Yoga and Meditation - Stress and Mindfulness 2021 (Spain)
- Yoga and Meditation - Mental Health Summit 2021 (Czech Republic)
- Yoga, Meditation and Mindfulness - Psychology Health 2021 (Hungary)
