Therapeutic Targets and Mechanisms for Treatment
Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutics is directed to cope with the symptoms of the disease. Here we describe the efforts dedicated to attack the plaques and, in more detail, the process of neurofibrillary degeneration, linked to the presence of the hyperphosphorylated microtubule associated protein tau. We have identified the different putative targets for therapeutics and the current knowledge on them.
Treatment for Alzheimer's disease is entering a new and exciting phase, with several new drugs beginning clinical trials. Many of these new therapies are based on our best current understanding of the pathogenesis of Alzheimer's disease, and are designed to try to either slow or halt the progression of the disease. There are several different theories underlying the current efforts, and these are briefly reviewed. Therapies directed against some aspect of beta-amyloid formation, against neurofibrillary tangle formation and against the inflammatory response are all considered, as are the problems associated with each area. It is as yet unclear which, if any, of these approaches will be successful, but the high level of activity in each of these three fields provides some hope that an effective treatment for Alzheimer's disease is on the horizon.
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- Stages of Alzheimer’s disease - Alzheimers 2020 (Scotland)
- Stress and Traumatic disorders - Appliedpsychology 2020 (Switzerland)
- Stress, Anxiety and Depression - Psychiatry 2021 (Canada)
- Stress, Anxiety and Depression - Annual Mental Health 2021 (Netherlands)
- Stress, Anxiety and Depression - Psychology 2020 (UK)
- Stress, Anxiety and Depression - Positive Psychology 2021 (France)
- Stress, Anxiety and Depression Management - Mental Health Congress 2020 (Italy)
- Stress, Depression and Anxiety - Psychology Education 2020 (Italy)
- Stress, Depression and Anxiety - Addiction & Healthcare 2020 (Germany)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2020 (Canada)
- Stress, Depression and Anxiety: - Psych Central 2020 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2020 (France)
- Substance Abuse and Chemical Dependence - Addiction & Healthcare 2020 (Germany)
- Suicide and Self harm - Psychotherapy Conference 2020 (Canada)
- Suicide and Self harm - Psych Central 2020 (Canada)
- Suicide and Self harm - Mental Health Nursing 2020 (Canada)
- Suicide Prevention and Self-harm Reduction - Positive Psychology 2021 (France)
- Tele Psychiatry - Euro Psychiatric Nursing 2020 (France)
- Telepsychiatry - Euro Mental Health 2020 (Spain)
- Telepsychiatry - Psychosomatic Medicine 2020 (Netherlands)
- Telepsychiatry - PSYCHIATRY CONGRESS 2020 (Italy)
- The Impact of Mental Illness on Society - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Types of anxiety disorders include: - Psychotherapy Conference 2020 (Canada)
- Well-being and Flourishing - Positive Psychology 2021 (France)
- Wellness and Health Care - Annual Mental Health 2021 (Netherlands)
- White Collar Crime - Forensic 2020 (Czech Republic)
- Women and Mental Health - Psychosomatic Medicine 2020 (Netherlands)
- Women Mental Health - Euro Mental Health 2020 (Spain)
- Women Mental Health and Illness - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Women’s Health and Midwifery - Annual Mental Health 2021 (Netherlands)
- Women’s Mental Health and Midwifery - PSYCHIATRY CONGRESS 2020 (Italy)
- Women’s Psychology - Psychology 2020 (UK)
- Womens Mental Health - Psychiatry 2020 (UAE)
- Womens Mental Health - Mental Health Congress 2020 (Italy)
- Yoga & Medication - Mental Health Congress 2020 (Italy)
- Yoga and Meditation - Stress and Mindfulness 2020 (France)
- Yoga, Meditation and Mindfulness - Clinical Psychology 2020 (Austria)
- Yoga, Meditation and Spirituality - Positive Psychology 2021 (France)