Alzheimer’s disease Pathophysiology and Disease Mechanisms
Alzheimer’s disease (AD) is a progressive dementia with loss of neurons and the presence of two main microscopic neuropathological hallmarks: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early onset AD, a rare familial form, is caused due to mutation of one out of three genes: (amyloid precursor protein), (presenilin 2) or (presenilin 1). Sporadic form occurs usually after age of 65 and accounts for most cases; it most likely results from a combination of genetic and influence of enviornment. Confirmed risk factors for sporadic AD are age and the presence of the E4 allele of (Apo lipoprotein E). Amyloid plaques comprise mainly of the neurotoxic peptide amyloid (Aβ, Abeta), cleaved sequentially from a larger precursor protein (APP) by two enzymes: β-secretase (also called BACE1) and γ-secretase (comprising four proteins, presenilin is one of them). If APP is first cleaved by the enzyme α-secretase rather than β-secretase then Aβ is not formed.
Neurofibrillary tangles comprise mainly of the protein tau which binds with microtubules, which facilitating the neuronal transport system. Tau uncoupling from microtubules and aggregation into tangles inhibits transport and results in disassembly of microtubule. Phosphorylation of tau might have an important role in this. Selective vulnerability of neuronal systems such as the cholinergic, serotonergic, and noradrenergic and glutamatergic systems form the basis of current rational pharmacological treatment.
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- Psychiatry & Psychology - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychiatry and Mental Health - Psychiatry Mental health 2020 (Australia)
- Psychiatry and Neurology - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychiatry and Psychiatric Disorders - Psychology Education 2020 (Italy)
- Psychiatry and Psychiatric Disorders - Stress and Mindfulness 2020 (France)
- Psychiatry and Psychiatric Disorders - Addiction & Healthcare 2020 (Germany)
- Psychiatry and Psychological Disorders - World Psychiatrists 2020 (Australia)
- Psychiatry and Psychological Disorders - Addiction 2020 (UAE)
- Psychiatry and Psychological Disorders - Mental Health Congress 2020 (Italy)
- Psychiatry and Psychology - Appliedpsychology 2020 (Switzerland)
- Psychiatry and Psychology Practices - Psychology 2020 (UK)
- Psychiatry and Psychology Practices - Mental Health Congress 2020 (Italy)
- Psychiatry Credentials - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychiatry Mental health disorders: - Psych Central 2020 (Canada)
- Psychiatry Mental health disorders: - Neurologists Conference 2020 (Canada)
- Psychiatry Nursing - Euro Psychiatric Nursing 2020 (France)
- Psychiatry vs. Psychology - Euro Psychiatry 2020 (Austria)
- Psychiatry vs. Psychology - PSYCHIATRY CONGRESS 2020 (Italy)
- Psychoanalysis and Psychometrics - Euro Psychiatry 2020 (Austria)
- Psychoanalysis and Psychometrics - PSYCHIATRY CONGRESS 2020 (Italy)
- Psychoanalysis, Psychosis and Psychometrics - Psychology Education 2020 (Italy)
- Psychological and Brain Sciences - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychological and Psychosocial Interventions - Psychology Education 2020 (Italy)
- Psychological Disorder - Clinical Psychology 2020 (Austria)
- Psychological Disorders - Clinical Psychologists 2020 (Singapore)
- Psychological Trauma - Euro Mental Health 2020 (Spain)
- Psychologist - Psychiatric Congress 2020 (France)
- Psychologists Meetings - Psychology 2020 (UK)
- Psychology - Psychosomatic Medicine 2020 (Netherlands)
- Psychology - Psychology 2020 (UK)
- Psychology - World Psychiatrists 2020 (Australia)
- Psychology - Psychiatric Congress 2020 (France)
- Psychology & Psychiatry - Psychosomatic Medicine-2020 (UK)
- Psychology & Psychiatry - Psychology 2020 (UK)
- Psychology & Psychiatry - Mental Health Congress 2020 (Italy)
- Psychology & Psychiatry - Psychiatry 2020 (Scotland)
- Psychology and Clinical Psychology - Psychiatry 2020 (Netherlands)
- Psychology and Cognitive Science - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychology and Human Resilience - Addiction & Healthcare 2020 (Germany)
- Psychology and Human Resilience - Psychology Education 2020 (Italy)
- Psychology and Psychological Disorders - Stress and Mindfulness 2020 (France)
- Psychology and Psychological Disorders - Psychology Health 2020 (Netherlands)
- Psychology Awareness - Psychology 2020 (UK)
- Psychology Case Reports - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychology Credentials - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Psychology Health - World Psychiatrists 2020 (Australia)
- Psychopathology and Pharmacotherapy - Stress and Mindfulness 2020 (France)
- Psychopathology and Psychoanalysis - Psychology Health 2020 (Netherlands)
- Psychopathology and Psychopathy - Euro Psychiatry 2020 (Austria)
- Psychopathology and Psychopathy - PSYCHIATRY CONGRESS 2020 (Italy)
- Psychopathology and Psychotherapy - Psychology 2020 (UK)
- Psychopharmacology - Psychology 2020 (UK)
- Psychopharmacology - Psychiatry Meet 2020 (UAE)
- Psychopharmacology - Addiction 2020 (UAE)
- Psychopharmacology - Euro Mental Health 2020 (Spain)
- Psychopharmacology - Euro Psychiatry 2020 (Austria)
- Psychopharmacology - Psychosomatic Medicine 2020 (Netherlands)
- Psychopharmacology - Psychosomatic Medicine-2020 (UK)
- Psychopharmacology Role: Psychology - Psychology 2020 (UK)
- Psychopharmacology Roles: Mental Health - Mental Health Congress 2020 (Italy)
- Psychosis - Euro Psychiatric Nursing 2020 (France)
- Psychosis - Mental Health Nursing 2020 (Canada)
- Psychosis and Psychological Assessment - Stress and Mindfulness 2020 (France)
- Psychosis and Psychometrics - Psychology Health 2020 (Netherlands)
- Psychosis, Medication and Early Intervention - Psychiatry Mental health 2020 (Australia)
- Psychosis: - Psych Central 2020 (Canada)
- Psychosis: - Neurologists Conference 2020 (Canada)
- Psychosis: - Psychotherapy Conference 2020 (Canada)
- Psychosomatic Disorders - Psychosomatic Medicine 2020 (Netherlands)
- Psychosomatic Disorders - Psychosomatic Medicine-2020 (UK)
- Psychosomatic Disorders - Psychology 2020 (UK)
- Psychosomatic disorders & medicine - Psychiatry Meet 2020 (UAE)
- Psychosomatic Disorders & Psychosomatic Medicine - PSYCHIATRY CONGRESS 2020 (Italy)
- Psychosomatic Medicine - Psychiatry 2020 (Netherlands)
- Psychosomatic Medicine - Psychosomatic Medicine 2020 (Netherlands)
- Psychosomatic Medicine - Mental Health Congress 2020 (Italy)
- Psychosomatic medicine - Psychiatric Congress 2020 (France)
- Psychosomatic Treatment - Psychosomatic Medicine-2020 (UK)
- Psychotherapist - Psychiatric Congress 2020 (France)
- Psychotherapy - Psychology 2020 (UK)
- Psychotherapy - Psychiatry Meet 2020 (UAE)
- Psychotherapy - Clinical Psychologists 2020 (Singapore)
- Psychotherapy - Psychosomatic Medicine-2020 (UK)
- Psychotherapy - Psychosomatic Medicine 2020 (Netherlands)
- Psychotherapy - Psychiatric Congress 2020 (France)
- Psychotherapy and Anger Management - Stress and Mindfulness 2020 (France)
- Psychotherapy and Psychopharmacology - Psychology Health 2020 (Netherlands)
- Psychotherapy disorders - Psychotherapy Conference 2020 (Canada)
- Psychotherapy disorders: - Psychotherapy Conference 2020 (Canada)
- Psychotherapy Treatment - World Psychiatrists 2020 (Australia)
- Public Health Nursing - Mental Health Nursing 2020 (Canada)
- Recent Advancement in Treatments of Dementia - Alzheimers 2020 (Scotland)
- Rehabilitation and Recovery - Clinical Psychology 2020 (Austria)
- Rehabilitation Therapy and Counseling - Addiction & Healthcare 2020 (Germany)
- Relaxation - Clinical Psychologists 2020 (Singapore)
- Research, Education and Case studies on Mental health - Psychiatry Mental health 2020 (Australia)
- Research, Education and Case Studies on Mental Health - Euro Psychiatric Nursing 2020 (France)
- Researches and Case studies on Psychiatry and Mental Health - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Resistant Depressive Disorder - Depression Congress 2020 (Turkey)
- Schizophrenia - World Psychiatrists 2020 (Australia)
- Schizophrenia - Psychiatric Congress 2020 (France)
- Schizophrenia - Mental Health Congress 2020 (Japan)
- Schizophrenia - Psychiatry 2020 (Netherlands)
- Schizophrenia and Bipolar Disorders - Psychology Education 2020 (Italy)
- Schizophrenia and Bipolar Disorders - Psychology Health 2020 (Netherlands)
- Schizophrenia and Nursing Care - Psychiatry Mental health 2020 (Australia)
- Science of Psychology and Applied Research - Psychology Education 2020 (Italy)
- Self-harm and Suicide Prevention - Addiction & Healthcare 2020 (Germany)
- Self-harm and Suicide Prevention - Psychology Health 2020 (Netherlands)
- Self-harm and Suicide Prevention - Psychology Education 2020 (Italy)
- Self-harm and Suicide Prevention - Stress and Mindfulness 2020 (France)
- Self-harm and Suicide Prevention - Psychosomatic Medicine-2020 (UK)
- Sexual Abuse - Psychiatric Congress 2020 (France)
- Sexual Abuse and Substance Use Disorders - Appliedpsychology 2020 (Switzerland)
- Sexual Psychiatric Disorder - World Psychiatrists 2020 (Australia)
- Sexual Psychiatric Disorder - Psychosomatic Medicine-2020 (UK)
- Sleep Disorder - World Psychiatrists 2020 (Australia)
- Sleep Disorder and Medicine - Psychiatry Mental health 2020 (Australia)
- Sleep Disorders - Psychosomatic Medicine 2020 (Netherlands)
- Sleep Disorders - Appliedpsychology 2020 (Switzerland)
- Sleep Disorders - PSYCHIATRY CONGRESS 2020 (Italy)
- Sleeping Disorder & Treatment - Psychiatry Meet 2020 (UAE)
- Social Neuroscience- Neuroimaging and Neuroplasticity - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Social Psychology - Euro Psychiatry 2020 (Austria)
- Social Psychology - Clinical Psychologists 2020 (Singapore)
- Social Psychology - Clinical Psychology 2020 (Austria)
- Social Psychology - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Social Science and Humanities - Psychology Health 2020 (Netherlands)
- Social Support and Health - Appliedpsychology 2020 (Switzerland)
- Sociology - Forensic 2020 (Czech Republic)
- Speech Language Pathology - Psychiatry 2020 (Netherlands)
- Stages of Alzheimer’s disease - Alzheimers 2020 (Scotland)
- Stress and Anxiety - Mental Health Congress 2020 (Japan)
- Stress and Traumatic disorders - Appliedpsychology 2020 (Switzerland)
- Stress, Anxiety and Depression - Psychiatry Mental health 2020 (Australia)
- Stress, Anxiety and Depression - Psychiatry 2020 (Netherlands)
- Stress, Anxiety and Depression - Psychology 2020 (UK)
- Stress, Anxiety and Depression - Psychosomatic Medicine-2020 (UK)
- Stress, Anxiety and Depression Management - Mental Health Congress 2020 (Italy)
- Stress, Anxiety and Depression Management - Psychiatry Meet 2020 (UAE)
- Stress, Depression and Anxiety - Psychology Health 2020 (Netherlands)
- Stress, Depression and Anxiety - Psychology Education 2020 (Italy)
- Stress, Depression and Anxiety - Addiction & Healthcare 2020 (Germany)
- Stress, Depression and Anxiety: - Psych Central 2020 (Canada)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2020 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2020 (France)
- Substance Abuse and Chemical Dependence - Addiction & Healthcare 2020 (Germany)
- Suicide and Self harm - Mental Health Nursing 2020 (Canada)
- Suicide and Self harm - Psych Central 2020 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2020 (Canada)
- Suicide Prevention - Depression Congress 2020 (Turkey)
- Suicide Prevention - Depression Congress 2020 (Turkey)
- Suicide Prevention - Psychiatric Congress 2020 (France)
- Tele Psychiatry - Euro Psychiatric Nursing 2020 (France)
- Telepsychiatry - Psychosomatic Medicine 2020 (Netherlands)
- Telepsychiatry - Euro Mental Health 2020 (Spain)
- Telepsychiatry - PSYCHIATRY CONGRESS 2020 (Italy)
- The Impact of Mental Illness on Society - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Therapeutic Targets and Mechanisms for Treatment - Alzheimer’s Disease-2020 (Czech Republic)
- Transactional analysis - Clinical Psychologists 2020 (Singapore)
- Types of anxiety disorders include: - Psychotherapy Conference 2020 (Canada)
- Vascular Dementia - Alzheimer’s Disease-2020 (Czech Republic)
- White Collar Crime - Forensic 2020 (Czech Republic)
- Women and Mental Health - Psychosomatic Medicine 2020 (Netherlands)
- Women Mental Health - Euro Mental Health 2020 (Spain)
- Women Mental health and Illness - Psychiatric Congress 2020 (France)
- Women Mental Health and Illness - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Women Mental health and Illness - World Psychiatrists 2020 (Australia)
- Women’s Mental Health and Disorders - Euro Psychiatry 2020 (Austria)
- Women’s Mental Health and Midwifery - PSYCHIATRY CONGRESS 2020 (Italy)
- Women’s Psychology - Psychology 2020 (UK)
- Womens Mental Health - Psychiatry 2020 (Scotland)
- Womens Mental Health - Mental Health Congress 2020 (Italy)
- Yoga & Medication - Mental Health Congress 2020 (Italy)
- Yoga & Meditation - Psychosomatic Medicine-2020 (UK)
- Yoga and Meditation - Stress and Mindfulness 2020 (France)
- Yoga, Meditation and Mindfulness - Clinical Psychology 2020 (Austria)
- Yoga, Meditation and Mindfulness - Psychology Health 2020 (Netherlands)