Alzheimer’s disease Pathophysiology and Disease Mechanisms
Alzheimer’s disease (AD) is a progressive dementia with loss of neurons and the presence of two main microscopic neuropathological hallmarks: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early onset AD, a rare familial form, is caused due to mutation of one out of three genes: (amyloid precursor protein), (presenilin 2) or (presenilin 1). Sporadic form occurs usually after age of 65 and accounts for most cases; it most likely results from a combination of genetic and influence of enviornment. Confirmed risk factors for sporadic AD are age and the presence of the E4 allele of (Apo lipoprotein E). Amyloid plaques comprise mainly of the neurotoxic peptide amyloid (Aβ, Abeta), cleaved sequentially from a larger precursor protein (APP) by two enzymes: β-secretase (also called BACE1) and γ-secretase (comprising four proteins, presenilin is one of them). If APP is first cleaved by the enzyme α-secretase rather than β-secretase then Aβ is not formed. Neurofibrillary tangles comprise mainly of the protein tau which binds with microtubules, which facilitating the neuronal transport system. Tau uncoupling from microtubules and aggregation into tangles inhibits transport and results in disassembly of microtubule. Phosphorylation of tau might have an important role in this. Selective vulnerability of neuronal systems such as the cholinergic, serotonergic, and noradrenergic and glutamatergic systems form the basis of current rational pharmacological treatment.
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- Self-harm and Suicide Prevention - Annual Mental Health 2021 (Spain)
- Self-harm and Suicide Prevention - Psychology Health 2021 (Hungary)
- Sleep Disorder and Medicine - Psychiatry Mental health 2021 (Belgium)
- Sleep Disorders - Psychiatric 2021 (USA)
- Sleep Disorders - Psychiatry Conference 2022 (France)
- Sleep Disorders - Psychiatry Congress 2021 (France)
- Social Psychology - Euro Psychiatry 2022 (Italy)
- Social Psychology - Psychiatry Conference 2022 (France)
- Social Psychology and Covid-19 - Psychiatry Conference 2021 (Germany)
- Social Science and Humanities - Psychology Health 2021 (Hungary)
- Sociology - Forensic 2021 (Czech Republic)
- Stress - Psychiatric Congress 2021 (Netherlands)
- Stress and Pain Management - Mental Health Summit 2021 (Czech Republic)
- Stress Management - Mental Health Congress 2021 (Germany)
- Stress, Anxiety and Depression - Psychology 2021 (UK)
- Stress, Anxiety and Depression - Psychiatry Mental health 2021 (Belgium)
- Stress, Anxiety and Depression - Psychiatry Meet 2021 (France)
- Stress, Anxiety and Depression - Annual Mental Health 2021 (Spain)
- Stress, Depression and Anxiety - Psychology Health 2021 (Hungary)
- Stress, Depression and Anxiety: - Psychologists Psychiatrists 2021 (Canada)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2021 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2021 (Spain)
- Suicidal Risk - Mental Health Congress 2021 (Germany)
- Suicide and Self harm - Mental Health Summit 2021 (Czech Republic)
- Suicide and Self harm - Mental Health Nursing 2021 (Canada)
- Suicide and Self harm - Psychologists Psychiatrists 2021 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2021 (Canada)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicidology and Suicide Prevention - Psychiatric Congress 2021 (Netherlands)
- Telepsychiatry - Psychiatry Congress 2021 (France)
- The Psychological and Social Impact of Covid-19 - Psychologists Meet 2021 (Netherlands)
- The role of psychiatrists during Covid-19 - Psychiatry Conference 2021 (Germany)
- Therapeutic Targets and Mechanisms for Treatment - Alzheimer’s disease 2021 (UK)
- Track 10: Emergency Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 11: Stress and pain management - Psychiatry Summit 2022 (Czech Republic)
- Track 12: Palliative and Hospice - Psychiatry Summit 2022 (Czech Republic)
- Track 13: Neuroscience and Neuropsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 14: Sports, Social and Military Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 15: Psychosomatic Medicine - Psychiatry Summit 2022 (Czech Republic)
- Track 16: Experimental Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 17: Yoga and Meditation - Psychiatry Summit 2022 (Czech Republic)
- Track 18: Forensic Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 19: Alzheimer’s and Dementia - Psychiatry Summit 2022 (Czech Republic)
- Track 1: Psychiatry and Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 20: Research, Education and Case Studies on Mental Health - Psychiatry Summit 2022 (Czech Republic)
- Track 2: Child and Adolescent Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 3: Mental Health and Psychiatric Nursing - Psychiatry Summit 2022 (Czech Republic)
- Track 4: Addiction Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 5: Telepsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 6: Anxiety and Depression Disorders - Psychiatry Summit 2022 (Czech Republic)
- Track 7: Midwifery & Women’s Health - Psychiatry Summit 2022 (Czech Republic)
- Track 8: Cross Cultural Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 9: Human Cognition - Psychiatry Summit 2022 (Czech Republic)
- TRAUMA - Psychiatry Congress 2022 (Czech Republic)
- Trauma Stress-Related Disorders - Psychiatry Conference 2022 (France)
- Vascular Dementia - Alzheimer’s disease 2021 (UK)
- Vestibular Disorders - EURONEURO 2021 (France)
- Wellness and Health Care - Annual Mental Health 2021 (Spain)
- Women and Mental Health - Psychiatric 2021 (USA)
- Women Mental Health and Illness - Psychiatry Meet 2021 (France)
- Women Mental Health and Illness In times of Covid-19 - Psychiatry Conference 2021 (Germany)
- Women’s Health and Midwifery - Annual Mental Health 2021 (Spain)
- Women’s Mental Health and Disorders - Euro Psychiatry 2022 (Italy)
- Women’s Mental Health and Midwifery - Psychiatry Congress 2021 (France)
- Women’s Psychology - Psychology 2021 (UK)
- Womens Mental Health - Psychiatry Congress 2021 (Germany)
- Yoga and Meditation - Stress and Mindfulness 2021 (Spain)
- Yoga and Meditation - Mental Health Summit 2021 (Czech Republic)
- Yoga, Meditation and Mindfulness - Psychology Health 2021 (Hungary)
