Alzheimer’s disease Pathophysiology and Disease Mechanisms
Alzheimer’s disease (AD) is a progressive dementia with loss of neurons and the presence of two main microscopic neuropathological hallmarks: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early onset AD, a rare familial form, is caused due to mutation of one out of three genes: (amyloid precursor protein), (presenilin 2) or (presenilin 1). Sporadic form occurs usually after age of 65 and accounts for most cases; it most likely results from a combination of genetic and influence of enviornment. Confirmed risk factors for sporadic AD are age and the presence of the E4 allele of (Apo lipoprotein E). Amyloid plaques comprise mainly of the neurotoxic peptide amyloid (Aβ, Abeta), cleaved sequentially from a larger precursor protein (APP) by two enzymes: β-secretase (also called BACE1) and γ-secretase (comprising four proteins, presenilin is one of them). If APP is first cleaved by the enzyme α-secretase rather than β-secretase then Aβ is not formed. Neurofibrillary tangles comprise mainly of the protein tau which binds with microtubules, which facilitating the neuronal transport system. Tau uncoupling from microtubules and aggregation into tangles inhibits transport and results in disassembly of microtubule. Phosphorylation of tau might have an important role in this. Selective vulnerability of neuronal systems such as the cholinergic, serotonergic, and noradrenergic and glutamatergic systems form the basis of current rational pharmacological treatment.
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Alzheimer’s disease Pathophysiology and Disease Mechanisms Conference Speakers
Recommended Sessions
- Alzheimer’s disease
- Alzheimer’s disease and Type 2 Diabetes
- Alzheimer’s disease Diagnosis and Symptoms
- Alzheimer’s disease Imaging
- Alzheimer’s disease Pathophysiology and Disease Mechanisms
- Amyloid Protein in Alzheimer’s and Dementia
- Animal Models and Translational Medicine
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- Psychoanalysis and Psychometrics - Euro Psychiatry 2022 (Italy)
- Psychoanalysis and Psychometrics - Psychiatry Congress 2021 (France)
- Psychoanalysis and Psychosis - Mental Health Summit 2021 (Czech Republic)
- Psychoanalysis, Psychosis and Psychometrics - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Psychological and Psychosocial Interventions - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Psychological Disorder - Clinical Psychology 2021 (Austria)
- Psychological disorders - Psychologists Meet 2021 (Netherlands)
- Psychological Evaluation & Assessment - Psychiatric Congress 2022 (Aland Islands)
- Psychological problems associated with COVID-19 - Psychologists Meet 2021 (Netherlands)
- Psychologists Meetings - Psychology 2021 (UK)
- Psychology - Psychosomatic Medicine 2022 (UK)
- Psychology - Psychology 2021 (UK)
- Psychology - Psychologists Meet 2021 (Netherlands)
- Psychology - Mental Health Summit 2021 (Czech Republic)
- Psychology - Psychiatric 2021 (USA)
- Psychology & Psychiatry - Psychology 2021 (UK)
- Psychology & Psychiatry - Mental Health 2022 (Germany)
- Psychology and Human Resilience - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Psychology and Human Resilience - Annual Mental Health 2022 (France)
- Psychology and Psychological Disorders - Psychology Health 2021 (Hungary)
- Psychology and Psychological Resilience - Stress and Mindfulness 2021 (Spain)
- Psychology and Psychotherapy - Mental Health Congress-2021 (Singapore)
- Psychology Awareness - Psychology 2021 (UK)
- Psychology, Autism and Youth Protection - Positive Psychology 2022 (France)
- Psychometrics, Psychosis and Psychological Assessment: - Stress and Mindfulness 2021 (Spain)
- PSYCHOPATHOLOGY & PSYCHOTHERAPY - Psychiatry Congress 2022 (Czech Republic)
- Psychopathology and Antidepressants - Stress and Mindfulness 2021 (Spain)
- Psychopathology and Antidepressants - Stress and Mindfulness 2021 (Spain)
- Psychopathology and Psychoanalysis - Psychology Health 2021 (Hungary)
- Psychopathology and Psychopathy - Psychiatry Congress 2021 (France)
- Psychopathology and Psychopathy - Euro Psychiatry 2022 (Italy)
- Psychopathology and Psychotherapy - Psychology 2021 (UK)
- Psychopharmacology - Psychiatric 2021 (USA)
- Psychopharmacology - Addiction 2021 (Netherlands)
- Psychopharmacology - World Psychiatry 2021 ()
- Psychopharmacology - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Psychopharmacology - Euro Psychiatry 2022 (Italy)
- Psychopharmacology - Psychosomatic Medicine 2022 (UK)
- Psychopharmacology - Psychology 2021 (UK)
- Psychopharmacology and Neuropharmacology - Annual Mental Health 2022 (France)
- Psychopharmacology Role: Mental Health - Mental Health 2022 (Germany)
- Psychopharmacology Role: Psychology - Psychology 2021 (UK)
- PSYCHOSIS - Psychiatry Congress 2022 (Czech Republic)
- Psychosis - Psychiatric Congress 2022 (Aland Islands)
- Psychosis and Psychometrics - Psychology Health 2021 (Hungary)
- Psychosis, Medication and Early Intervention - Psychiatry Mentalhealth 2022 (Singapore)
- Psychosis: - Psychologists Psychiatrists 2021 (Canada)
- Psychosis: - Neuro Experts 2021 (Canada)
- Psychosis: - Psychotherapy Conference 2021 (Canada)
- Psychosocial Rehabilitation - Psychiatric Congress 2022 (Aland Islands)
- Psychosomatic Disorders - Psychiatric 2021 (USA)
- Psychosomatic Disorders - Mental Health 2022 (Germany)
- Psychosomatic Disorders - Mental Health Congress 2022 (Japan)
- Psychosomatic Disorders - Psychology 2021 (UK)
- Psychosomatic Disorders - Psychosomatic Medicine 2022 (UK)
- Psychosomatic Disorders & Psychosomatic Medicine - Psychiatry Congress 2021 (France)
- Psychosomatic Medicine - Psychiatric 2021 (USA)
- Psychosomatic medicine - World Psychiatry 2021 ()
- Psychosomatic Medicine - Psychosomatic Medicine 2022 (UK)
- Psychosomatic medicine - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Psychosomatic Medicine and Sleep Medicine - Euro Neuro 2021 (France)
- Psychotherapies - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Psychotherapy - Psychiatric 2021 (USA)
- Psychotherapy - Psychiatry Conference 2022 (France)
- Psychotherapy - Mental Health Summit 2021 (Czech Republic)
- Psychotherapy - Psychology 2021 (UK)
- Psychotherapy - Psychosomatic Medicine 2022 (UK)
- Psychotherapy and Counceling - Stress and Mindfulness 2021 (Spain)
- Psychotherapy and Counselling Psychology - Positive Psychology 2022 (France)
- Psychotherapy and its Advances - Psychiatric Congress 2022 (Aland Islands)
- Psychotherapy and Psychopharmacology - Psychology Health 2021 (Hungary)
- Psychotherapy/Analysis - Euro Neuro 2021 (France)
- Public Health and Patient Safety - Annual Mental Health 2022 (France)
- Regenerative medicine - Mental Health Summit 2021 (Czech Republic)
- Rehabilitation and Family Therapies - Addiction 2021 (Netherlands)
- Rehabilitation and Recovery - Clinical Psychology 2021 (Austria)
- Research, Education and Case studies on Mental Health - Psychiatry Mentalhealth 2022 (Singapore)
- Resistant depressive disorder - Depression Congress 2021 (France)
- Role of Tele-Psychiatry during Lockdown - Psychiatric 2021 (USA)
- Schizophrenia - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Schizophrenia - Mental Health Summit 2021 (Czech Republic)
- Schizophrenia - Psychiatric Congress 2022 (Aland Islands)
- SCHIZOPHRENIA - Psychiatry Congress 2022 (Czech Republic)
- Schizophrenia - World Psychiatry 2021 ()
- Schizophrenia - Mental Health Congress 2022 (Japan)
- Schizophrenia and Bipolar Disorders - Stress and Mindfulness 2021 (Spain)
- Schizophrenia and Bipolar Disorders - Mental Health Congress 2022 (Japan)
- Schizophrenia and Bipolar Disorders - Annual Mental Health 2022 (France)
- Schizophrenia and Bipolar Disorders - Psychology Health 2021 (Hungary)
- Schizophrenia and Bipolar Disorders - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Schizophrenia and Bipolar Disorders - Stress and Mindfulness 2021 (Spain)
- Schizophrenia and Nursing Care - Psychiatry Mentalhealth 2022 (Singapore)
- Schizophrenia and Obsessive Compulsive Disorder (OCD) - Mental Health Congress-2021 (Singapore)
- Schizophrenia/Psychosis - Euro Neuro 2021 (France)
- Science of Psychology and Applied Research - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Seizure Disorders - Euro Neuro 2021 (France)
- Self-harm and Suicide Prevention - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Self-harm and Suicide Prevention - Psychology Health 2021 (Hungary)
- Self-harm and Suicide Prevention - Mental Health Congress 2022 (Japan)
- Self-Harm and Suicide Prevention - Stress and Mindfulness 2021 (Spain)
- Sexual Orientation and LGBT - Positive Psychology 2022 (France)
- Sleep Disorder - Mental Health Congress 2022 (Japan)
- Sleep Disorder and Medicine - Psychiatry Mentalhealth 2022 (Singapore)
- Sleep Disorders - Psychosomatic Medicine 2022 (UK)
- Sleep Disorders - Psychiatry Conference 2022 (France)
- Sleep Disorders - Psychiatry Congress 2021 (France)
- Sleep Disorders - Psychiatric 2021 (USA)
- Social Psychology - Euro Psychiatry 2022 (Italy)
- Social Psychology - Clinical Psychology 2021 (Austria)
- Social Psychology - Psychiatry Conference 2022 (France)
- Social Science and Humanities - Psychology Health 2021 (Hungary)
- Sports psychology - World Psychiatry 2021 ()
- Sports psychology - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Stress - Psychiatric Congress 2022 (Aland Islands)
- Stress and Anxiety - Mental Health Congress 2022 (Japan)
- Stress and Pain Management - Mental Health Summit 2021 (Czech Republic)
- Stress, Anxiety and Depression - Mental Health 2022 (Germany)
- Stress, Anxiety and Depression - Positive Psychology 2022 (France)
- Stress, Anxiety and Depression - Psychology 2021 (UK)
- Stress, Anxiety and Depression - Psychiatry Mentalhealth 2022 (Singapore)
- Stress, Anxiety and Depression - Annual Mental Health 2022 (France)
- Stress, Depression and Anxiety - Psychology Health 2021 (Hungary)
- Stress, Depression and Anxiety - PSYCHOLOGY EDUCATION 2022 (Hungary)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2021 (Canada)
- Stress, Depression and Anxiety: - Psychologists Psychiatrists 2021 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2021 (Spain)
- Suicide and Self harm - Mental Health Summit 2021 (Czech Republic)
- Suicide and Self harm - Psychologists Psychiatrists 2021 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2021 (Canada)
- Suicide Prevention - Depression Congress 2021 (France)
- Suicide Prevention - Depression Congress 2021 (France)
- Suicide Prevention (Disponible en español) - World Psychiatry 2021 ()
- Suicide Prevention (Disponible en español) - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Suicidology and Suicide Prevention - Psychiatric Congress 2022 (Aland Islands)
- Technology and the Future of Mental Health Treatment - World Psychiatry 2021 ()
- Technology and the Future of Mental Health Treatment - WORLD PSYCHIATRIC CONGRESS-2021 (Spain)
- Telepsychiatry - Psychosomatic Medicine 2022 (UK)
- Telepsychiatry - Psychiatry Congress 2021 (France)
- The Psychological and Social Impact of Covid-19 - Psychologists Meet 2021 (Netherlands)
- Theory, Religion and Language - Positive Psychology 2022 (France)
- Track 10: Emergency Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 11: Stress and pain management - Psychiatry Summit 2022 (Czech Republic)
- Track 12: Palliative and Hospice - Psychiatry Summit 2022 (Czech Republic)
- Track 13: Neuroscience and Neuropsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 14: Sports, Social and Military Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 15: Psychosomatic Medicine - Psychiatry Summit 2022 (Czech Republic)
- Track 16: Experimental Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 17: Yoga and Meditation - Psychiatry Summit 2022 (Czech Republic)
- Track 18: Forensic Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 19: Alzheimer’s and Dementia - Psychiatry Summit 2022 (Czech Republic)
- Track 1: Psychiatry and Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 20: Research, Education and Case Studies on Mental Health - Psychiatry Summit 2022 (Czech Republic)
- Track 2: Child and Adolescent Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 3: Mental Health and Psychiatric Nursing - Psychiatry Summit 2022 (Czech Republic)
- Track 4: Addiction Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 5: Telepsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 6: Anxiety and Depression Disorders - Psychiatry Summit 2022 (Czech Republic)
- Track 7: Midwifery & Women’s Health - Psychiatry Summit 2022 (Czech Republic)
- Track 8: Cross Cultural Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 9: Human Cognition - Psychiatry Summit 2022 (Czech Republic)
- TRAUMA - Psychiatry Congress 2022 (Czech Republic)
- Trauma Stress-Related Disorders - Psychiatry Conference 2022 (France)
- Vestibular Disorders - Euro Neuro 2021 (France)
- Women and Mental Health - Psychiatric 2021 (USA)
- Women and Mental Health - Psychosomatic Medicine 2022 (UK)
- Women and Mental Health - Mental Health Congress 2022 (Japan)
- Women’s Health and Midwifery - Annual Mental Health 2022 (France)
- Women’s Mental Health - Mental Health 2022 (Germany)
- Women’s Mental Health and Disorders - Euro Psychiatry 2022 (Italy)
- Women’s Mental Health and Midwifery - Psychiatry Congress 2021 (France)
- Women’s Psychology - Psychology 2021 (UK)
- Yoga and Meditation - Mental Health Summit 2021 (Czech Republic)
- Yoga and Meditation - Stress and Mindfulness 2021 (Spain)
- Yoga, Meditation and Mindfulness - Clinical Psychology 2021 (Austria)
- Yoga, Meditation and Mindfulness - Psychology Health 2021 (Hungary)
- Yoga, Meditation and Spirituality - Positive Psychology 2022 (France)