Alzheimer’s disease Pathophysiology and Disease Mechanisms
Alzheimer’s disease (AD) is a progressive dementia with loss of neurons and the presence of two main microscopic neuropathological hallmarks: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early onset AD, a rare familial form, is caused due to mutation of one out of three genes: (amyloid precursor protein), (presenilin 2) or (presenilin 1). Sporadic form occurs usually after age of 65 and accounts for most cases; it most likely results from a combination of genetic and influence of enviornment. Confirmed risk factors for sporadic AD are age and the presence of the E4 allele of (Apo lipoprotein E). Amyloid plaques comprise mainly of the neurotoxic peptide amyloid (Aβ, Abeta), cleaved sequentially from a larger precursor protein (APP) by two enzymes: β-secretase (also called BACE1) and γ-secretase (comprising four proteins, presenilin is one of them). If APP is first cleaved by the enzyme α-secretase rather than β-secretase then Aβ is not formed.
Neurofibrillary tangles comprise mainly of the protein tau which binds with microtubules, which facilitating the neuronal transport system. Tau uncoupling from microtubules and aggregation into tangles inhibits transport and results in disassembly of microtubule. Phosphorylation of tau might have an important role in this. Selective vulnerability of neuronal systems such as the cholinergic, serotonergic, and noradrenergic and glutamatergic systems form the basis of current rational pharmacological treatment.
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- Social Support and Health - Appliedpsychology 2020 (Switzerland)
- Sociology - Forensic 2020 (Czech Republic)
- Speech Language Pathology - Psychiatry 2021 (Canada)
- Stages of Alzheimer’s disease - Alzheimers 2020 (Scotland)
- Stress and Traumatic disorders - Appliedpsychology 2020 (Switzerland)
- Stress, Anxiety and Depression - Psychiatry 2021 (Canada)
- Stress, Anxiety and Depression - Annual Mental Health 2021 (Netherlands)
- Stress, Anxiety and Depression - Psychology 2020 (UK)
- Stress, Anxiety and Depression - Positive Psychology 2021 (France)
- Stress, Anxiety and Depression Management - Mental Health Congress 2020 (Italy)
- Stress, Depression and Anxiety - Psychology Education 2020 (Italy)
- Stress, Depression and Anxiety - Addiction & Healthcare 2020 (Germany)
- Stress, Depression and Anxiety: - Psych Central 2020 (Canada)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2020 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2020 (France)
- Substance Abuse and Chemical Dependence - Addiction & Healthcare 2020 (Germany)
- Suicide and Self harm - Psych Central 2020 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2020 (Canada)
- Suicide and Self harm - Mental Health Nursing 2020 (Canada)
- Suicide Prevention and Self-harm Reduction - Positive Psychology 2021 (France)
- Tele Psychiatry - Euro Psychiatric Nursing 2020 (France)
- Telepsychiatry - Psychosomatic Medicine 2020 (Netherlands)
- Telepsychiatry - Euro Mental Health 2020 (Spain)
- Telepsychiatry - PSYCHIATRY CONGRESS 2020 (Italy)
- The Impact of Mental Illness on Society - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Types of anxiety disorders include: - Psychotherapy Conference 2020 (Canada)
- Well-being and Flourishing - Positive Psychology 2021 (France)
- Wellness and Health Care - Annual Mental Health 2021 (Netherlands)
- White Collar Crime - Forensic 2020 (Czech Republic)
- Women and Mental Health - Psychosomatic Medicine 2020 (Netherlands)
- Women Mental Health - Euro Mental Health 2020 (Spain)
- Women Mental Health and Illness - PSYCHIATRY CONFERENCE 2020 (Czech Republic)
- Women’s Health and Midwifery - Annual Mental Health 2021 (Netherlands)
- Women’s Mental Health and Midwifery - PSYCHIATRY CONGRESS 2020 (Italy)
- Women’s Psychology - Psychology 2020 (UK)
- Womens Mental Health - Mental Health Congress 2020 (Italy)
- Womens Mental Health - Psychiatry 2020 (UAE)
- Yoga & Medication - Mental Health Congress 2020 (Italy)
- Yoga and Meditation - Stress and Mindfulness 2020 (France)
- Yoga, Meditation and Mindfulness - Clinical Psychology 2020 (Austria)
- Yoga, Meditation and Spirituality - Positive Psychology 2021 (France)