Alzheimer’s disease Pathophysiology and Disease Mechanisms
Alzheimer’s disease (AD) is a progressive dementia with loss of neurons and the presence of two main microscopic neuropathological hallmarks: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early onset AD, a rare familial form, is caused due to mutation of one out of three genes: (amyloid precursor protein), (presenilin 2) or (presenilin 1). Sporadic form occurs usually after age of 65 and accounts for most cases; it most likely results from a combination of genetic and influence of enviornment. Confirmed risk factors for sporadic AD are age and the presence of the E4 allele of (Apo lipoprotein E). Amyloid plaques comprise mainly of the neurotoxic peptide amyloid (Aβ, Abeta), cleaved sequentially from a larger precursor protein (APP) by two enzymes: β-secretase (also called BACE1) and γ-secretase (comprising four proteins, presenilin is one of them). If APP is first cleaved by the enzyme α-secretase rather than β-secretase then Aβ is not formed. Neurofibrillary tangles comprise mainly of the protein tau which binds with microtubules, which facilitating the neuronal transport system. Tau uncoupling from microtubules and aggregation into tangles inhibits transport and results in disassembly of microtubule. Phosphorylation of tau might have an important role in this. Selective vulnerability of neuronal systems such as the cholinergic, serotonergic, and noradrenergic and glutamatergic systems form the basis of current rational pharmacological treatment.
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Alzheimer’s disease Pathophysiology and Disease Mechanisms Conference Speakers
Recommended Sessions
- Alzheimer’s disease
- Alzheimer’s disease and Type 2 Diabetes
- Alzheimer’s disease Diagnosis and Symptoms
- Alzheimer’s disease Imaging
- Alzheimer’s disease Pathophysiology and Disease Mechanisms
- Amyloid Protein in Alzheimer’s and Dementia
- Animal Models and Translational Medicine
- Care Practice and Awareness
- Causes and Prevention of Alzheimer’s
- Current Research in Therapeutic Targets
- Front temporal Dementia
- Geriatrics and Cognitive Disorder
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- Managing Dementia
- Neurodegenerative Diseases
- Therapeutic Targets and Mechanisms for Treatment
- Vascular Dementia
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- Schizophrenia and Bipolar Disorders - Stress and Mindfulness 2021 (Spain)
- Schizophrenia and Bipolar Disorders - Psychology Health 2021 (Hungary)
- Schizophrenia and Nursing Care - Psychiatry Mental health 2021 (Belgium)
- Schizophrenia/Psychosis - EURONEURO 2021 (France)
- Seizure Disorders - EURONEURO 2021 (France)
- Self-harm and Suicide Prevention - Annual Mental Health 2021 (Spain)
- Self-harm and Suicide Prevention - Psychosomatic Medicine-2021 (Spain)
- Self-Harm and Suicide Prevention - Stress and Mindfulness 2021 (Spain)
- Self-harm and Suicide Prevention - Psychology Health 2021 (Hungary)
- Self-harm and Suicide Prevention - Psychiatry Meet 2021 (France)
- Semantic Disease - Alzheimer 2021 (USA)
- Sexual Psychiatric Disorder - Psychosomatic Medicine-2021 (Spain)
- Sleep Disorder and Medicine - Psychiatry Mental health 2021 (Belgium)
- Sleep Disorders - Psychiatry Congress 2021 (France)
- Social Psychology - Clinical Psychology 2021 (Austria)
- Social Psychology and Covid-19 - Psychiatry Conference 2021 (Germany)
- Social Science and Humanities - Psychology Health 2021 (Hungary)
- Sociology - Forensic 2021 (Czech Republic)
- Speech-language Pathology and Techniques - Autism 2021 (France)
- sports psychology - Psychiatric congress-2021 (Spain)
- Stress - Psychiatric Congress 2021 (France)
- Stress Management - Mental Health Congress 2021 (Germany)
- Stress, Anxiety and Depression - Psychiatry Mental health 2021 (Belgium)
- Stress, Anxiety and Depression - Annual Mental Health 2021 (Spain)
- Stress, Anxiety and Depression - Psychology 2021 (UK)
- Stress, Anxiety and Depression - Psychosomatic Medicine-2021 (Spain)
- Stress, Anxiety and Depression - Psychiatry Meet 2021 (France)
- Stress, Depression and Anxiety - Psychology Health 2021 (Hungary)
- Stress, Depression and Anxiety: - Psychologists Psychiatrists 2021 (Canada)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2021 (Canada)
- Stress, Depression, Anxiety and Mindfulness - Autism 2021 (France)
- Stress, Types, Causes and Management - Stress and Mindfulness 2021 (Spain)
- Substance Use and Mental Health - Psychiatric congress-2021 (Spain)
- Suicidal Risk - Mental Health Congress 2021 (Germany)
- Suicide and Self harm - Psychologists Psychiatrists 2021 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2021 (Canada)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicide Prevention (Disponible en español) - Psychiatric congress-2021 (Spain)
- Suicidology and Suicide Prevention - Psychiatric Congress 2021 (France)
- Technology and the Future of Mental Health Treatment - Psychiatric congress-2021 (Spain)
- Telepsychiatry - Psychiatry Congress 2021 (France)
- The Psychological and Social Impact of Covid-19 - Psychologists Meet 2021 (Netherlands)
- The role of psychiatrists during Covid-19 - Psychiatry Conference 2021 (Germany)
- Therapeutic Targets and Mechanisms for Treatment - Alzheimer’s disease 2021 (Czech Republic)
- Vaccination and Nursing Care - Autism 2021 (France)
- Vascular Dementia - Alzheimer 2021 (USA)
- Vascular Dementia - Alzheimer’s disease 2021 (Czech Republic)
- Vestibular Disorders - EURONEURO 2021 (France)
- Wellness and Health Care - Annual Mental Health 2021 (Spain)
- Women Mental Health and Illness - Psychiatry Meet 2021 (France)
- Women Mental Health and Illness In times of Covid-19 - Psychiatry Conference 2021 (Germany)
- Women’s Health and Midwifery - Annual Mental Health 2021 (Spain)
- Women’s Mental Health and Midwifery - Psychiatry Congress 2021 (France)
- Women’s Psychology - Psychology 2021 (UK)
- Womens Mental Health - Psychiatry Congress 2021 (Germany)
- Yoga & Meditation - Psychosomatic Medicine-2021 (Spain)
- Yoga and Meditation - Stress and Mindfulness 2021 (Spain)
- Yoga, Meditation and Mindfulness - Clinical Psychology 2021 (Austria)
- Yoga, Meditation and Mindfulness - Psychology Health 2021 (Hungary)
