Animal Models and Translational Medicine
Animal models for Alzheimer’s disease it is important to think about the human phenotype and what is being modeled in terms of the animal phenotype. The moderator, Bradley Hyman, professor of neurology at Harvard Medical School, said that animal models of Alzheimer’s disease, based on the genetics of the disease and the closely related frontotemporal dementia, replicate at least some of the pathology. Researchers have been successful at modeling very specific aspects of Alzheimer’s disease in the mouse (e.g., plaques, tangles). Although these are incomplete models of the human disease, they have been well received in the field as potentially relevant models for use in drug discovery.
Patients with Alzheimer’s disease will display both amyloidopathy and tauopathy; however, scientists often focus, in a reductionist way, on one or the other in an animal model. A participant added that even though the anatomy in the mouse is different than the human, mutant tau mice are relatively good models in that they recapitulate tau-dependent neurodegeneration. This has led a number of companies to focus on antibodies that block tau-dependent neurodegeneration in these mouse models.
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Recommended Sessions
- Alzheimer’s disease
- Alzheimer’s disease and Type 2 Diabetes
- Alzheimer’s disease Diagnosis and Symptoms
- Alzheimer’s disease Imaging
- Alzheimer’s disease Pathophysiology and Disease Mechanisms
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- Animal Models and Translational Medicine
- Care Practice and Awareness
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- Current Research in Therapeutic Targets
- Front temporal Dementia
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- Social Psychology - Psychiatry Conference 2022 (France)
- Social Psychology and Covid-19 - Psychiatry Conference 2021 (Germany)
- Social Science and Humanities - Psychology Health 2021 (Hungary)
- Sociology - Forensic 2021 (Czech Republic)
- Stress - Psychiatric Congress 2021 (Netherlands)
- Stress and Pain Management - Mental Health Summit 2021 (Czech Republic)
- Stress Management - Mental Health Congress 2021 (Germany)
- Stress, Anxiety and Depression - Psychology 2021 (UK)
- Stress, Anxiety and Depression - Psychiatry Mental health 2021 (Belgium)
- Stress, Anxiety and Depression - Psychiatry Meet 2021 (France)
- Stress, Anxiety and Depression - Annual Mental Health 2021 (Spain)
- Stress, Depression and Anxiety - Psychology Health 2021 (Hungary)
- Stress, Depression and Anxiety: - Psychologists Psychiatrists 2021 (Canada)
- Stress, Depression and Anxiety: - Psychotherapy Conference 2021 (Canada)
- Stress, Types, Causes and Management - Stress and Mindfulness 2021 (Spain)
- Suicidal Risk - Mental Health Congress 2021 (Germany)
- Suicide and Self harm - Mental Health Summit 2021 (Czech Republic)
- Suicide and Self harm - Mental Health Nursing 2021 (Canada)
- Suicide and Self harm - Psychologists Psychiatrists 2021 (Canada)
- Suicide and Self harm - Psychotherapy Conference 2021 (Canada)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicide Prevention - Depression Congress 2021 (Switzerland)
- Suicidology and Suicide Prevention - Psychiatric Congress 2021 (Netherlands)
- Telepsychiatry - Psychiatry Congress 2021 (France)
- The Psychological and Social Impact of Covid-19 - Psychologists Meet 2021 (Netherlands)
- The role of psychiatrists during Covid-19 - Psychiatry Conference 2021 (Germany)
- Therapeutic Targets and Mechanisms for Treatment - Alzheimer’s disease 2021 (UK)
- Track 10: Emergency Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 11: Stress and pain management - Psychiatry Summit 2022 (Czech Republic)
- Track 12: Palliative and Hospice - Psychiatry Summit 2022 (Czech Republic)
- Track 13: Neuroscience and Neuropsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 14: Sports, Social and Military Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 15: Psychosomatic Medicine - Psychiatry Summit 2022 (Czech Republic)
- Track 16: Experimental Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 17: Yoga and Meditation - Psychiatry Summit 2022 (Czech Republic)
- Track 18: Forensic Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 19: Alzheimer’s and Dementia - Psychiatry Summit 2022 (Czech Republic)
- Track 1: Psychiatry and Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 20: Research, Education and Case Studies on Mental Health - Psychiatry Summit 2022 (Czech Republic)
- Track 2: Child and Adolescent Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 3: Mental Health and Psychiatric Nursing - Psychiatry Summit 2022 (Czech Republic)
- Track 4: Addiction Psychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 5: Telepsychiatry - Psychiatry Summit 2022 (Czech Republic)
- Track 6: Anxiety and Depression Disorders - Psychiatry Summit 2022 (Czech Republic)
- Track 7: Midwifery & Women’s Health - Psychiatry Summit 2022 (Czech Republic)
- Track 8: Cross Cultural Psychology - Psychiatry Summit 2022 (Czech Republic)
- Track 9: Human Cognition - Psychiatry Summit 2022 (Czech Republic)
- TRAUMA - Psychiatry Congress 2022 (Czech Republic)
- Trauma Stress-Related Disorders - Psychiatry Conference 2022 (France)
- Vascular Dementia - Alzheimer’s disease 2021 (UK)
- Vestibular Disorders - EURONEURO 2021 (France)
- Wellness and Health Care - Annual Mental Health 2021 (Spain)
- Women and Mental Health - Psychiatric 2021 (USA)
- Women Mental Health and Illness - Psychiatry Meet 2021 (France)
- Women Mental Health and Illness In times of Covid-19 - Psychiatry Conference 2021 (Germany)
- Women’s Health and Midwifery - Annual Mental Health 2021 (Spain)
- Women’s Mental Health and Disorders - Euro Psychiatry 2022 (Italy)
- Women’s Mental Health and Midwifery - Psychiatry Congress 2021 (France)
- Women’s Psychology - Psychology 2021 (UK)
- Womens Mental Health - Psychiatry Congress 2021 (Germany)
- Yoga and Meditation - Stress and Mindfulness 2021 (Spain)
- Yoga and Meditation - Mental Health Summit 2021 (Czech Republic)
- Yoga, Meditation and Mindfulness - Psychology Health 2021 (Hungary)
