Multiple Sclerosis

Multiple sclerosis is a chronic enervating demyelinating disease of the central nervous system, caused by an immunological attack resulting in the progressive loss of myelin sheath on neuronal axons. The resultant decrease in the speed of signal transduction leads to a loss of functionality that includes both cognitive and motor impairment depending on the location of the lesion.

The progression of multiple sclerosis occurs due to episodes of increasing inflammation, which is proposed to be due to the release of antigens such as myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein, causing an autoimmune response. Multiple sclerosis presents itself as a spectrum based on the degree of inflammation; a majority of patients suffer from early relapsing and remitting episodes of neuronal deterioration following a period of recovery.

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