Huntingtons disease
Huntington's disease (HD) is a rare chromosome dominant neurodegenerative disorder caused is caused by polyglutamine tract enlargement in the huntingtin gene, resulting in the mutant huntingtin gene (HTT). It is characterized by loss of medium spiny neurons and astrogliosis. The primary brain region to be substantially affected is the striate body, followed by degeneration of the frontal and temporal cortices. The striatum's subthalamic nuclei send control signals to the Globus Pallidus that starts and modulates motion.
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