18^th International Conference on Alzheimer's disease and Dementia September 19-20, 2024 Paris, France

Tetsumori Yamashima MD, PhD is a consultant neurosurgeon specialized in neuroscience. In 1975, he graduated from Kanazawa University Faculty of Medicine. In 1979, he completed his research diploma in the Kanazawa University Graduate School Medical Research Course (Doctor of Medicine). He then studied abroad in Germany and Sweden, including neuropathology and brain science. He became Chief of Medical Staff at Kanazawa University Hospital, Associate Professor of Kanazawa University Medical Faculty, and Director of Restorative Neurosurgery at Kanazawa University Graduate School of Medical Science. At present, he is CEO of the Arimatsu Medical and Dental Clinic in Kanazawa city, works at this clinic (Tuesday to Saturday), and at Minami-gaoka Hospital (consultant neurosurgeon: Monday mornings). At Kanazawa University Hospital (part-time lecturer: Monday afternoons), he heads a special “higher brain dysfunction” outpatient clinic. He is acknowledged for using the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status), MRI and PET scans for early detection of Alzheimer’s disease, even a few years before dementia appears, allowing preventive treatment to be carried out. In 1998, he proposed the “calpain-cathepsin hypothesis” as a mechanism of neuronal cell death. He also discovered that the causative agent responsible for Alzheimer’s disease is not amyloid β, but hydroxynonenal derived from “cooking oil”. He is the author of 200 published scientific papers in English, and 75 papers and 15 books in Japanese.

Alzheimer’s disease, Dementia

Yong Shen did his B.Sc (1979-1983) in Physiology in Nanjing university, M.sc (1986-1989) in Neurophysiology in Physiology Institute, Academia Sinica, Laboratory of Behavioral Neuroscience and Ph.D (1986-1989) in neuroscience in State university of New York at Binghamton.

Yong shen′s research interests includes Molecular cellular mechanisms of neuron and glial functions for related diseases, Roles of neuroimmunology in neuronal degeneration and regeneration, Molecular cloning and characterization of novel genes related with brain disorders, Development of clinical diagnostic markers for brain disorders Alzheimer and Parkinson’s diseases, Identification of small molecules as potential drugs for brain disorders, Mechanisms of Learning and memory

Dr. Videnovic obtained his M.D at the University of Belgrade School of Medicine, where he subsequently completed an internship in Internal medicine followed by a residency in Anatomic pathology. From 1998 to 2000 he was a postdoctoral fellow in the Department of Pharmacology at the University of Illinois in Chicago, where he worked on the neurobiology of the sleep apnea syndrome. He subsequently moved to the Rush Alzheimer′s Disease Center in Chicago, where he worked on several NIH funded clinical-pathological studies of aging. Dr Videnovic completed an internship in Internal medicine at MCP Hahnemann University Hospital in Philadelphia, and a Neurology residency at Northwestern University Feinberg School of Medicine in Chicago where he served as chief resident. Subsequently he trained in Movement Disorders at Rush University Medical Center in Chicago, and sleep medicine at Northwestern University. He obtained a Master of Science degree in clinical research from the Rush Graduate College in 2007. He was appointed as Assistant Professor of Neurology at Northwestern University Feinberg School of Medicine in July 2007. Dr. Videnovic is a member of the American Academy of Neurology, the Parkinson Study Group, and the American Academy of Sleep Medicine. Dr. Videnovic cares for patients with Parkinson′s disease and various movement disorders. He is a principal investigator and co-investigator on several clinical trials in the field of Parkinson′s disease and movement disorders. His research focuses on sleep dysfunction in neurodegenerative disorders, particularly Parkinson′s disease.

Aleksander research focuses on sleep dysfunction in neurodegenerative disorders, particularly Parkinsons disease.

Dott Federico Bilotta, MD, PhD Full-time Attendant Anesthesiologist, Department of Anesthesiology, Critical Care and Pain Medicine, University of Rome “La Sapienza”, Rome Italy. Full Professor in Clinical Anesthesiology at the Albert Einstein College of Medicine, The Bronx, New York, NY, USA Author of more than 68 indexed papers, Total Impact Factor (2010) >237 Recognition and Awards Bilotta F, Caramia R, Paoloni FP, Delfini R, Rosa G. Safety and Efficacy of Intensive Insulin Therapy in Critical Neurosurgical Patients. Anesthesiology 2009;110(3):611-9. This article was chosen by the American Society of Anesthesiologists for a World Press Release and to provide Continuing Medical Education points in the USA Bilotta F, Doronzio A, Cuzzone V, Caramia R, Rosa G. Early Postoperative Cognitive Recovery and Gas Exchange Patterns After Balanced Anesthesia With Sevoflurane or Desflurane in Overweight and Obese Patients Undergoing Craniotomy: A Prospective Randomized Trial. Journal Neurosurgical Anesthesiology 2009;21(3):207-13. This article was chosen and a summary is reported by Faculty 1000 in Medicine 2009 According Review in Anesthesiology 2009, Borgeat A, Brennan TJ, Elsenach JC. Advancing Medicine in Anesthesiology. Anesthesiology 2009; 111: 1192-96 the paper: “Bilotta F, Caramia R, Paoloni FP, Delfini R, Rosa G. Safety and Efficacy of Intensive Insulin Therapy in Critical Neurosurgical Patients. Anesthesiology 2009;110(3):611-9” has been selected among the 12 more representative articles published in Anesthesiology in 2009. Teaching Award: University of Southern California, The Keck School of Medicine and the Department of Anesthesiology as International Visiting Professor “Outstanding teaching contribution” Journal Club and Grand Rounds Lecture, October 21-22, 2010.

Dott Federico Bilotta research interests are in Neurosurgical Anesthesiology.

Dr. Shashi Kant Tiwari obtained his Ph.D. (Biological Sciences), from Academy of Scientific and Innovative Research (AcSIR), New Delhi, India and Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, India in 2015. During doctoral research program, he extensively worked on cellular and molecular mechanisms of environmental toxicants mediated neurodevelopmental as well as neurodegenerative disorders in both in vivo and in vitro model system. In addition, he also found that nanotized curcumin and an anti-epileptic drug enhances the pool of endogenous neural stem cells (NSCs) and activating signals that instruct these stem cells to generate new neurons during neurodegenerative conditions. Before joining his PhD program, Dr. Tiwari received Junior Research Fellowship/National Eligibility Test (CSIR-UGC-JRF/NET), Graduate Aptitude Test in Engineering (GATE) by Govt. of India in 2008. After PhD, he joined as Post-Doctoral Fellow in Department of Pediatrics, University of California, San Diego, USA. His research activities examine how NSCs respond to the cues such as environmental toxicants, drugs, pathogens (Zika and HIV) and various neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The current research focuses of Dr. Tiwari are on investigating the viral mediated neuronal injury in human embryonic stem cell (hESCs)/ human induced pluripotent stem cells (hiPSCs) derived 2D neurons, astrocytes, microglia and 3D brain organoid model system. Besides these, Dr. Tiwari’s work is also focusing on the role of RNA epitranscriptomic modifications in neurological disorders. He has over 20 National and International publications, abstracts Indexed in 5 International conferences. He is also an editorial board member of various reputed journals.

Cellular and Molecular Neurotoxicology, Stem Cell Biology and regenerative medicine, RNA Biology

Eef Hogervorst did her Ph.D. at Maastricht University in age related cognitive decline and treatment at the Department of Psychiatry and Neuropsychology in 1998. She was subsequently employed at the University of Oxford (Oxford Project to Investigate Memory and Ageing, OPTIMA) as a neuropsychologist and epidemiologist and was awarded several grants and prizes for her research into early diagnoses and risk factors for dementia and cognitive decline. Eef did similar research as a Research Associate Professor at the Donald W. Reynolds Department of Geriatrics (ranked 8th nationally) of the University of Arkansas Medical Sciences and at the University of Cambridge (Department of Psychiatry) as Senior Research Associate, before taking on a Chair in Psychology at Loughborough University which is consistently ranked among the top Universities in the U.K. Eef has set-up collaborations with several large multi-centre observational and treatment studies for age related cognitive decline and dementia (EPIC NORFOLK and MRC CFAS in the U.K. and the H ABC, WHIMS and KEEPS studies in the U.S.A and a large cohort in Indonesia). She studies cross cultural clinical diagnostic accuracy of different types of dementias and has developed and validated a computerized expert system and cognitive test battery for this purpose with Dr Bandelow. Eef is an elected member of the MRC College of Experts for Neuroscience and Mental Health, a member of the European Scientific Referee panel for the European Research Area in Ageing and is often asked to review research proposals (Alzheimer Association, NWO, SPARC etc) and papers in her field (Neurology, JNNP, Arch Neurol, etc). She was invited as a keynote speaker at several conferences (e.g. ICAD). At Oxford Eef was Somerville Junior Research fellow and Blasschko fellow at Linacre College. Eef is an elected young Fellow at the Royal Society of Medicine in London, Editor (Section Head) of the International Faculty 1000, on the editorial board of JAD and has over 100 international peer reviewed publications.

Her research includes the use of standardized questionnaires to investigate risk & protective factors for dementia & age-related cognitive decline which is funded by the Alzheimer’s Research Trust & other bodies, such as the New Dynamics of Ageing. Also involved in exercise, sex steroid and nutritional treatment programs to improve cognitive function & mood in the elderly.

Dr. Taraben was Born in Damascus, Syria, in 1959. He is a U.S. citizen, married (Laila Tarabein), has a daughter, and currently lives on the gulf coast in south Alabama. He pursued his training in France and the USA. He founded neurology and spinal interventional center in south Alabama that grew to become the leading center in the area, which served the entire southeast states for over 21 years until he retired from practice in 2017. Dr. Taraben is now active mentoring physicians with lectures and workshops on Spinal Interventions, besides writing, editing,and speaking at the national and international arenas.

Neurologist and Spinal Interventionist

Dr. Othman Ghribi is an Associate professor at the Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, USA. He obtained his PHD degree in Neuropharmacology from Rene Descartes University, Paris, France in 1994. He published four book chapters, invited review papers and has more than 50 publications in different peer reviewed journals. Dr. Ghribi holds grants from the Centers of Biomedical Research Excellence and the National Institute of Environmental health Sciences/The National Institute of Health. Dr Ghribi obtained the Alzheimers and Related Diseases Research Award from the Virginia Center on Aging as well as the Dean David Wilson Academic Award in Neuroscience from the University of North Dakota.

Othman Ghribis Interests include role of the diet and environmental factors in Alzheimers and Parkinsons diseases, Tyrosine hydroxylase, alpha-synuclein, LXRs, Estrogen receptors, Oxysterols, Endoplasmic reticulum stress, Apoptosis, IGF-1, Leptin.

Efrat Received M.Sc. and Ph.D. from The Hebrew University in Jerusalem, Israel. Was a postdoctoral fellow in the Department of Biochemistry followed by assistant research scientist in the Department of Pathology, both at New York University School of Medicine, New York, New York. Currently is an Associate Professor in the Departments of Psychiatry and Pharmacology, New York University School of Medicine, New York, New York and in the Center for Dementia Research, Nathan S. Kline Institute, Orangeburg, New York.

Efrat′s Research interests are treatment targets for Alzheimer’s Disease and other neurodegenerative disorders. The focus is on discovering genetic mutations and allelic variations involved in hereditary forms of amyloidoses; characterizing the regulation of amyloid precursor proteins processing; defining processes involved in the conversion of soluble protein to the insoluble, oligomeric and fibrillar forms; identifying factors that inhibit oligomerization and fertilization of amyloid proteins; and identifying factors that prevent disease-driven neurodegeneration

Alejandro De La Parra Solomon is an entrepreneur based in Tallinn, Estonia that is focused on the Information Technology, Education, Health, International Trade, and Real Estate industry sectors. He is creative, results-driven, and has 18+ years of Digital Strategy experience in IT architecture, marketing, and IT implementation. Alejandro De La Parra Solomon serves as CEO and Cofounding Partner at The Solomon Brokerage Firm / Solomon Real Estate, and functions as Chief Strategy Officer at Quantum Brain Research Institute in Estonia. He is also the Lead Digital Strategist of the VTBCommunity Foundation, a predictable finance-focused blockchain initiative in Gibraltar. Within the academic and educational fields, Alejandro De La Parra Solomon acted as the Executive Vice President: Executive Chairman of the WAMS Mobile Health Division, WAMS Chief Coordinating Officer, a member of the WAMS Executive Council (WAMS Executive Board), a member of the WAMS Education & Training Board (ETB), a member of the WAMS Editorial Board, an Honorary Member of the Academy Faculty FWAMS, an Honorary Fellow of the Academy & is also a Senior Partner at WAMS, The World Academy of Medical Sciences. He is also an Advisory Board member, functioned as the Chief Operating Officer, and is a Co-founding Partner at The Reprogramming Medicine Association. He is also a member of Singularity University and of OpenExo. In relation to nonprofit organizations, he has served as a member of the Laurentia Project and of Cerebro Mexico. He currently serves as an Advisory Board member of the Lifeboat Foundation and as an Advisory Board member of the Future Worlds Center – Cyprus Neuroscience & Technology Institute (Senior TV Program). He is a voting citizen and is running for Mayor and as a future Parliamentary Candidate at Asgardia. He also served as the founder and former Board of Directors of Astrum Fundacion, and was the Digital Strategy Advisor for POKI Ciudad Organica. He is also a part of the General Member Board at the National Autism Association, the National Fibromyalgia Association, the International Literacy Association, and the United Spinal Association. In the logistics and international trade sector, Alejandro De La Parra Solomon is the former President & Co-founder of PetroM Renewable, and served as Vice President of Operations & Strategy at PetroM Corp across all of its divisions, including PetroM Logistics. In the Biotech sphere, Alejandro De La Parra Solomon served as COO & Co-founder at RegenerAge Clinic & RegenerAge Beauty. He is the former CEO & Founder of Astrum Salud Movil and its Telemedicine service Astrum Movil, former Digital Strategy Director & Co-founder of Dr. Jois, BiorganicAging, and What Skin Needs/WSN International Pty. Ltd. He also served as a member of the Board of Advisors and is former Chief Marketing Officer at ReAnima Advanced Biosciences, a project launched by Bioquark, Inc., where he was also serving as Digital Media Director. He also served as the Latin America Region Manager and Digital Strategy adviser at CardiacSense. In the editorial and publishing sector, Alejandro De La Parra Solomon is former CITO & Senior Partner of Cerezo Editores, an epistemology publishing company in Mexico. Alejandro De La Parra Solomon is also a member of several associations pertaining to Information Technology advocacy and development including the World Blockchain Association, the Computing Technology Industry Association, the Internet Marketing Association, the Application Developers Alliance, and the Association of Strategic Marketing. Alejandro De La Parra Solomon’s activities in arts & culture involve his membership in Sociedad de Autores y Compositores de Mexico (SACM). He also served as Digital Strategy Advisor at Xicome Festival. He is a multimedia professional featured in IMDB, SoundCloud, and ReverbNation and has had activities in the entertainment industry as a music producer, composer & arranger for Televisa with broadcast television, film, radio, and web, receiving international awards and aired content on more than 185 countries. In the energy sector, Alejandro De La Parra Solomon worked as the Vice President of Strategy & Operations of PetroM Energy, and is a member of the National Introducing Brokers Association, and a part of the National Biodiesel Board (Alliance Program).

(Neuroscience & Blockchain)