Day 1 :
- Alzheimer’s Disease
University of Wolverhampton, UK
Title: Association of egg consumption with the risk and prognosis of dementia among the older population
Dr Precious osayuki igbinigie is a postgraduate student at the university of Wolverhampton. He obtained his Masters of Public health degree from the university of Wolverhampton after studying optometry (OD) in Nigeria. Dr igbinigie worked at the public and private sector as an optometrist. His passion for public informed his decision in obtaining further academic knowledge studies having gained practical experience working in deprived area as an optometrist.
Dementia is one of the world's biggest health problems and is a significant public health challenge becoming more common as the aged population grows. There is no known cure for dementia; thus, more efforts have been made to investigate its risk or protective factors for prevention. Previous studies suggested moderate egg consumption (one egg per day) is not associated with cardiovascular disease. While a separate study reported intakes of eggs and cholesterol were related to higher all-cause, cardiovascular and cancer mortality. However, the increased mortality was attributed to cholesterol intake. Therefore, it is unclear whether the consumption of eggs was associated with the risk of dementia and the outcomes of people with dementia. Also, few studies have specifically examined factors influencing egg consumption in older people, despite the ageing world population. This research project aimed to conduct a systematic literature review, analyse data from case-control/cohort studies and discuss the determinants and impacts of egg consumption on the incidence and mortality of dementia in older people.
This study employed a systematic literature review and a quantitative approach based on a Guangzhou case-control study conducted from July to October 2020 in China. The study comprises 466 participants aged ≥50 (233 cases and 233 control, respectively). In addition, Chinese five province cohort data comprising 6071 participants aged ≥60 was conducted in 2007-2009. Using a standard interview method, participants' socio-economic status, disease risk factors and egg consumption over the past two years were documented at baseline, and this was followed up until 2012. The third study, the UK biobank prospective study, involves 500,000 participants aged 40-69 years drawn from the National Health register (NHS) since 2006.
- Care Practice and Awareness
Marie Christine Le Bourdais
, Alzheimer Society of Montreal
Title: ADRESSING STIGMA THROUGHT VIRTUAL FILM SCREENINGS AND PANEL DISCUSSIONS ON DEMENTIA : RESULTS FROM A PARTICIPATORY RESEARCH PROJECT IN A HEALTH PROMOTION PROGRAM
Marie Christine has next to 20 years of experience working with seniors, including more than a decade with a clientele living with neurocognitive disorders, caregivers and professionals in health and social services networks. She graduated in gerontology and now focuses on the issues related to aging from a multidisciplinary perspective, combining social work, psychology, and biology. This perspective gives her a global vision of the needs of the clientele she supports and offers a wide variety of solutions and innovations. Since she arrived in 2016 at the Alzheimer Society of Montreal, she has been a trainer, conference speaker and coordinator of clinical services. As a director, she now ensures that the needs of communities are aligned with the provided service. From her rich and varied expériences, Marie Christine now supports a team of 40 people in operationalizing ongoing projects based on a person-centred approach.
The Dementia Community Investment (DCI) in Canada fund was designed to support projects on quality of life of persons living with dementia (PLWD) and their carers and decrease the stigma around dementia. The aim of the project What connects Us ~ Ce qui nous lie (2020-2023) was to expand to a number of shared activities and events to address stigma, with communitybased and arts-related organizations, at the intersection of dementia, aging and mental health. In this presentation, we will present the initial results on the effectiveness of six online community screening of short film featuring stories about living with neurocognitive disorder (NCD), followed by curated panel discussions with the film directors, arts/culture partners, policy makers and other stakeholders, on stigma and misperception, from a panellist perspective. The research team employed a mixed methods ethnographic approach to describe and measure the impact of the six films screening with pre/post-film and then later post-film and later post-discussion measures of semantic sentiment. All discussions were simultaneously interpreted, and based on open-ended qualitative questions that had been developed with panellists prior to the screening. The qualitative questions asked for one word/phrase responses to generate work clouds. Three researchers then assessed the words/phrases until agreement on positive or negative value was reached. Participating as a panellist in this project had an impact on the understanding of the intersection of cultural and arts-related events and the sharing of personal stories on the perception of PLWD and the stigma around it. For participants, there was a significant change in sentiment from negative to positive sentiment across all waves within and across the six screenings, with the most change occurring post-discussion. Films about living with NCD, and curated questions developed in collaboration with panellists and director of 1st person experiences can positively impact changes in sentiment about NCDs.
- Alzheimers Disease
Beijing University of Chinese Medicine
Title: Effects and value of Chinese medicine nursing in Alzheimer’s disease
Jing Jiang has completed her PhD from the Department of Acupuncture /Moxibustion and Tuina, Beijing University of Chinese Medicine. She has been working as an associated Professor of School of Nursing, Beijing University of Chinese Medicine (BUCM) in China since 2016. She has published more than 40 papers in reputed journals and has been serving as the vice director of the center of Acupoint research in BUCM.
Currently, 50 million people worldwide suffered from dementia, among which Alzheimer's disease (AD) accounts for 70% of the total number of dementias . The main feature of AD is the obstacles of memory, thinking and behavior . It is estimated that by 2050, every 3 seconds a new case of Alzheimer's disease would be reported . Due to the lack of effective therapies for this disease, the current goal of AD treatment is to slow down the progress of neurodegeneration in the brain , so it pays more attention to symptoms relief and nursing. The aggravation of disease progress will make patients need more outside help in their daily life. Cultural differences have resulted in Chinese people preferring to live at home for a long time and prefer to be cared for by family members, so most AD patients in China were taken care of by family members . Although the Chinese government had increased nursing facilities for the elderly, most of dementia patients were still like to be cared at home . Because of the family members, as the caregivers, were lack of the professional knowledge about dementia, the cares of easy-to-perform and non-invasiveness were more friendly for these caregivers to help the AD patients to relieve the symptoms. Therefore, based on the current form of home care for AD in China, Chinese medicine nursing techniques played more and more important role. In this manuscript, we reviewed the situations of Chinese medicine nursing on AD patients , so as to try to help promote the road of AD care.
Strategies of Chinese Medicine Nursing Techniques Intervention in Alzheimer's Disease
In recent years, massage, moxibustion, ear acupoint pressing, acupoint application,scraping and other characteristic Chinese medical nursing techniques have gradually become a new topic in caring of AD. Since these technologies are easy to operate and master, they were suitable for caregivers to help patients perform at home for a long time, and could also improve the cognitive abilities of AD patients.
Researchers  selected DU20 (Baihui), EX-HN 1 (Sishencong) and other acupoints on the head to perform massage interventions on 42 patients with Alzheimer's disease. The Hasegawa Dementia Scale (HDS), Mini Mental Capacity Scale (MMSE), Ability of Daily Living Scale (ADL), and Quality of Life Scale (QOL-AD) were used to evaluate the patients before the intervention, at the end of 3 months and at the end of 6 months. The results showed that the effect of the intervention for 6 months was better than that of the intervention for 3 months and before the intervention. Long-term acupoint massage could delay the progress of the disease and promote cognitive ability recovery. Chronic diseases such as AD require a longer course of treatment, and the early stages of cognitive impairment were often accompanied by mental and behavioral symptoms . Among them, agitation behaviors such as walking, grabbing and biting, irritability, holding objects, and cursing were more common. In addition, research  also showed that hand massage could improve the agitation behavior of AD patients. Lin Meili  et al. treated a case of AD patients with scraping treatment and combined with cognitive function training for a total of 10 weeks, once a week, 2 hours for each time. After the course of treatment, the patients’ cognitive function and social function activities were significantly improved. Another clinical trial  randomly divided 60 AD patients into 2 groups, one group was given moxibustion every day, the other group was given oral medicine (Donepezil) every day. After 3 months of treatment, it was found that the moxibustion group performed better than medicine group in MMSE scores.
Moreover, different Chinese medicine nursing techniques combined could also produce better results. The results of two studies had shown that  ear acupoint pressing combined with acupoint massage could be better than single technique on AD patients in improving their cognitive function and daily living ability. So as to acupuncture combined with ear acupoint pressing. Studies found that stimulating related acupoints could promote brain blood flow, increase blood volume, and synthesize a large number of neurotransmitters in AD patients, thereby improving patients' cognitive function and improving the quality of life .
In summary, although the number of AD patients is increasing and no effective therapy to treat AD, at the initial stage of curing this disease, Chinese medicine nursing techniques still could provide a new angle for caregivers to care AD patients. In the future, more studies would provide more evidence of the mechanism and clinical efficacy of Chinese medicine nursing.
- Multiple Sclerosis
Assist Prof Dr Murugaiyan Gopal
Harvard Medical School
Title: Therapeutic targeting of microRNAs in multiple sclerosis
I obtained my Ph.D. in 2006 from the National Centre for Cell Science at Pune University under the supervision of Dr. Bhaskar Saha. During my doctoral period I have studied the role of dendritic cell (DC) expressed co-stimulatory molecule CD40 in the regulation of immune response to tumors. At the end of 2006, I joined the lab of Dr. Howard Weiner to pursue postdoctoral training. My current research is focused on understanding the role of DCs and microRNAs in the regulation of inflammatory and regulatory T cells in patients with multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE).
A disequilibrium between immunosuppressive Tregs and inflammatory IL-17–producing Th17 cells is a hallmark of autoimmune diseases, including multiple sclerosis (MS). However, the molecular mechanisms underlying the Treg and Th17 imbalance in CNS autoimmunity remain largely unclear. Identifying the factors that drive this imbalance is of high clinical interest. We found a major disease-promoting role for microRNA-92a (miR-92a) in CNS autoimmunity. miR-92a was elevated in experimental autoimmune encephalomyelitis (EAE), and its loss attenuated EAE. Mechanistically, miR-92a mediated EAE susceptibility in a T cell–intrinsic manner by restricting Treg induction and suppressive capacity, while supporting Th17 responses, by directly repressing the transcription factor Foxo1. Although miR-92a did not directly alter Th1 differentiation, it appeared to indirectly promote Th1 cells by inhibiting Treg responses. Correspondingly, miR-92a inhibitor therapy ameliorated EAE by concomitantly boosting Treg responses and dampening inflammatory T cell responses. Analogous to our findings in mice, miR-92a was elevated in CD4+ T cells from patients with MS, and miR-92a silencing in patients’ T cells promoted Treg development but limited Th17 differentiation. Together, our results demonstrate that miR-92a drives CNS autoimmunity by sustaining the Treg/Th17 imbalance and implicate miR-92a as a potential therapeutic target for MS.
- Estradiol in female cognitive function
Owner / Entreprenuer at Balance the Brain Professional Corp
Title: Importance of Estradiol in female cognitive function via neuroplasticity in the neuroendocrine system
Kelli started her nursing career in Obstetrics as an RN working in the Labor & Delivery, Nursery, and Post Partum units at Promedica Fremont Memorial Hospital. As a Women's Health Nurse Practitioner, she has worked at the gynecological setting at Neighborhood Health Association in Toledo, Ohio. She has worked in the primary care setting with her husband who is a family physician. Together they ran a private practice before joining Promedica Physicians Group in 2014. Kelli remained there until she, her husband and twin sons moved to Utah in August 2017 to enjoy the great outdoors! Kelli has 15 years of primary care and gynecology experience. Her goal is to help every teenager and woman develop the best version of themselves emotionally, socially, and spiritually. She is here to assist them in the many roles woman fulfill throughout their lifetime and encourage them to take care of themselves along the way through regular pap smear, mammogram screening, skin lesion and colon cancer screenings as well as depression screenings. She also encourages women to be proactive with a balanced diet and a cardioactive lifestyle to prevent obesity, diabetes and heart disease. She also has a special interest in endocrinology, PCOS and infertility.
In her spare time, Kelli enjoys spending time with husband John of 16 years and twin teenage sons here in Utah skiing, hiking, and off road jeeping. She enjoys photography, decorating and reading. Kelli also has 4 grown step-children in Ohio, two who have married and blessed them with a total of 3 grandkids.
- Behavioral Health
University of Massachusetts Amherst
Title: A Quality Improvement Project for Co-occurring Disorders in Outpatient Behavioral Health
Patients with mental health diagnoses often have co-occurring alcohol use disorders, which can exacerbate their psychiatric symptoms. A standardized assessment tool should be utilized for screening for alcohol use disorders in outpatient mental health programs so that interventions can be implemented when a co-occurring disorder is identified. The purpose of this project was to provide clinicians with education and to improve the process for screening patients with mental health disorders for problematic drinking behaviors to implement recommended interventions when appropriate to improve the overall quality of the patient’s care and increase the clinician’s knowledge and confidence in treating co-occurring disorders. Methods: The project design is a quality improvement model in a psychiatric intensive outpatient program that included education for clinicians, implementation of a standardized assessment tool and application of evidenced-based interventions for co-occurring disorders. The clinicians took a pre-test before the initial education session began and a post-test at the end and they participated in interviews throughout the entire project. Each education session included more evidenced-based interventions that clinicians could implement to improve the overall quality of care for their patients. The pre-tests, post-tests and interview data were collected, organized and analyzed for learning needs throughout the project and for evaluation and effectiveness of the interventions at the end of the project. Results: Out of 36 clinicians at the facility, 34 took the pre-test and 31 clinicians took the post-test. Findings revealed an increase in the mean scores of each of the Likert-scale questions on the post-tests after the education sessions were conducted except in question one because of a technical error. Qualitative data from interviews and responses to open-ended questions on the surveys were also collected, organized and analyzed. This qualitative data also indicated an improvement in the clinician’s knowledge and confidence in treating co-occurring disorders after the education sessions were provided. Conclusion: The participants of this project showed improvement in their knowledge and comfort level when assessing and treating patients with co-occurring disorders after participating in the education sessions. The short-term goals of the project were met, and clinicians also felt that the interventions were improving the overall quality of patient care. Future recommendations include adding a more comprehensive assessment for patients that scored positively on the AUDIT-C and continuing to provide education for clinicians on topics such as motivational interviewing, psychotropic medications, group psychotherapy and treatment and causes of delirium.
- Alzheimer Disease
Dr. Ghassan Taraben
American Board Certified Neurologist & Spinal Interventionist
Title: Dementia and Alzheimer are not a normal part of aging
Dr. Taraben was Born in Damascus, Syria, in 1959. He is a U.S. citizen, married (Laila Tarabein), has a daughter, and currently lives on the gulf coast in south Alabama. He pursued his training in France and the USA. He founded neurology and spinal interventional center in south Alabama that grew to become the leading center in the area, which served the entire southeast states for over 21 years until he retired from practice in 2017. Dr. Taraben is now active mentoring physicians with lectures and workshops on Spinal Interventions, besides writing, editing,and speaking at the national and international arenas.
Humans have 85 billion neurons at birth and lose 10,000 a day. • Age is the greatest known risk factor; most people with Alzheimer's are 65 and older. • If it affects a person under 65, it is referred to as earlyonset Alzheimer’s. • Alzheimer's is a progressive disease, a person with Alzheimer's lives 4 to 8 years after diagnosis but rarely can live as long as 20 years. • People with younger-onset Alzheimer’s can be in the disease's early, middle, or late stages. • Lifespan is greatly shortened in early-onset Alzheimer’s. Afflicted lives 4-8 years on average, up to 20 years max....